General Cell Lines and Cell Cultures
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Bladder, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx PathHunter CHO-K1 mFPR2 β-Arrestin Cell Line, 2 vials. (93-1034C2)
The PathHunter mFPR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. formylpeptides) based activation of mFPR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mFPR2 and EA-tagged β-Arrestin-2. Activation of mFPR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS p53 Nuclear Translocation Cell Line, 2 vials. (93-0757C3)
The PathHunter U2OS p53 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the p53 DNA damage pathway. This cell line enables assessment of ligand (e.g. camptothecin) based pathway activation via detection of resulting p53 nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged p53 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of p53 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Brain: Amygdala, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC Clostridioides difficile Strain 4111 genomic DNA
Genomic DNA isolated from Clostridioides difficile Strain 4111. This bacterial strain is also available as ATCC Catalog No. BAA-1871™.
Genscript Corporation CHO-K1/SST1/Gqi5 Stable Cell L
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner SST1 receptor is a Gi/Go-coupled GPCR which is expressed in pancreatic islets pituitary Cerebellum (Purkinje cells) frontal cortex (pyramidal cells) hippocampus (CA1-4 subfields and some granule cells of the dentate gyrus) It inhibits cAMP accumulation and stimulates tyrosine phosphatase activity it also can antiproliferation br GenScript s SST1-expressing stable cell line was made in CHO-K1/Gqi5 host cell and optimized for calcium assays
Eurofins Discoverx PathHunter U2OS TrkB Functional Assay, 2 vials. (93-0463C3)
The PathHunter U2OS TrkB Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkB dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged TrkB and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter U2OS c-MET/c-MET Dimerization Cell Line, 2 vials. (93-1063C3)
The PathHunter c-MET/c-MET Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. hepatocyte growth factor) induced dimerization of c-MET/c-MET receptors. This product uses EFC technology. The cell line included overexpresses c-MET target protein fused to PK alongside c-MET target protein fused to EA. Upon ligand-induced dimerization of c-MET/c-MET, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter CHO-K1 ADRA2A β-Arrestin Cell line, 2 vials. (93-0424C2)
The PathHunter ADRA2A cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRA2A GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADRA2A and EA-tagged β-Arrestin-2. Activation of ADRA2A stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 CALCRL-RAMP2 (AM1) β-Arrestin Cell Line, 2 vials. (93-0270C2)
The PathHunter CALCRL-RAMP2 (AM1) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. adrenomedullin) based activation of CALCRL GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CALCRL and EA-tagged β-Arrestin-2. Activation of CALCRL stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 ADCYAP1R1 (PAC1) β-Arrestin Cell Line, 2 vials. (93-0249C2)
The PathHunter ADCYAP1R1 (PAC1) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MECA) based activation of ADCYAP1R1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADCYAP1R1 and EA-tagged β-Arrestin-2. Activation of ADCYAP1R1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 P2RY11 β-Arrestin Cell Line, 2 vials. (93-0281C2)
The PathHunter P2RY11 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ATP) based activation of P2RY11 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged P2RY11 and EA-tagged β-Arrestin-2. Activation of P2RY11 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 TACR2 β-Arrestin Cell Line, 2 vials. (93-0238C2)
The PathHunter TACR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. substance P) based activation of TACR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TACR2 and EA-tagged β-Arrestin-2. Activation of TACR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 mGALR1 β-Arrestin Cell Pool, 2 vials. (93-0603P2)
The PathHunter mGALR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. galanin) based activation of mGALR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mGALR1 and EA-tagged β-Arrestin-2. Activation of mGALR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Vaginal Epithelial Cell Basal Medium, 485mL
Vaginal Epithelial Cell Basal Medium is a sterile, phenol-red-free, liquid tissue culture medium that can be used as one component in a complete ATCC Primary Cell Solutions system. This serum-free system can be used to support vaginal epithelial cells derived from a patient's vaginal tissue. Vaginal Epithelial Cell Basal Medium contains essential and non-essential amino acids, vitamins, other organic compounds, trace minerals, and inorganic salts. To support the proliferation and plating efficiency of various types of vaginal epithelial cells, Vaginal Cell Basal Medium must be used with the appropriate cell-specific growth kit. When using this complete media system, the growth of vaginal epithelial cells is supported without the use of feeder layers, extracellular matrix proteins, or other substrates.